DegronMD - Q9Y2L1(DIS3)

DIS3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D319G	TCGA-A5-A1OF	UCEC	TCGA	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1667
p.E321D	TCGA-AY-5543	COAD	TCGA	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.D319N	TCGA-EL-A3CT	THCA	TCGA	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1667
p.G317E	DO48385	BLCA	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2222
p.V304A	DO1555	BRCA	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2222
p.E306K	DO9796	COAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.E306K	DO220484	KICH	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.R314I	DO24150	LUAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.R314T	DO26042	LUAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.3056
p.V304L	DO45527	LUSC	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2222
p.L300F	DO220876	MELA	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1111
p.A303V	DO42033	UCEC	ICGC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1944
p.S306F	SIDM01577	Plasma Cell Myeloma	GDSC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.2778
p.A303T	WM-115	skin	COSMIC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.1944
p.R305Q	CAL-78	bone	COSMIC	VVLHDE	LIG_APCC_ABBA_1	308:313	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc