DegronMD

Uniprot ID: Q9Y2L1

Source protein: Exosome complex exonuclease RRP44

Source gene: DIS3

Class: LIG_APCC_ABBA_1

Location: 308:313

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.685

ASA_SCORE: 68.75

COIL: 0.4735

CONS_SCORE: 0.2397

DSS_SCORE: 0.5331

HELIX: 0.0917

FCONS_SCORE: 0.8505

RIG_SCORE: 0.7207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D319G	TCGA-A5-A1OF	UCEC	TCGA	VVLHDE	LIG_APCC_ABBA_1	0.1667
p.E321D	TCGA-AY-5543	COAD	TCGA	VVLHDE	LIG_APCC_ABBA_1	0.1111
p.D319N	TCGA-EL-A3CT	THCA	TCGA	VVLHDE	LIG_APCC_ABBA_1	0.1667
p.G317E	DO48385	BLCA	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.2222
p.V304A	DO1555	BRCA	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.2222
p.E306K	DO9796	COAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.2778
p.E306K	DO220484	KICH	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.2778
p.R314I	DO24150	LUAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.3056
p.R314T	DO26042	LUAD	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.3056
p.V304L	DO45527	LUSC	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.2222
p.L300F	DO220876	MELA	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.1111
p.A303V	DO42033	UCEC	ICGC	VVLHDE	LIG_APCC_ABBA_1	0.1944
p.S306F	SIDM01577	Plasma Cell Myeloma	GDSC	VVLHDE	LIG_APCC_ABBA_1	0.2778
p.A303T	WM-115	skin	COSMIC	VVLHDE	LIG_APCC_ABBA_1	0.1944
p.R305Q	CAL-78	bone	COSMIC	VVLHDE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2L1	Exosome complex exonuclease RRP44	LIG_APCC_ABBA_1	308:313	VVLHDE	APC,CDC20,FZR1	0.685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons