DegronMD - Q9Y2P8(RCL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P172H	TCGA-DJ-A2QB	THCA	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.3056
p.P172H	DO39421	THCA	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.3056
p.E166K	TCGA-EO-A22U	UCEC	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.E166K	DO43755	UCEC	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1389
p.V173M	TCGA-KK-A6E2	PRAD	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.6097
p.V173M	DO51356	PRAD	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation altering degron motif	0.6097
p.C163F	DO229027	LICA	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0556
p.D168N	EVSA-T	breast	COSMIC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.1944
p.I191M	NCI-H446	lung	COSMIC	VRKVLKPIQ	DEG_APCC_DBOX_1	173:181	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons