DegronMD

Uniprot ID: Q9Y2P8

Source protein: RNA 3'-terminal phosphate cyclase-like protein

Source gene: RCL1

Class: DEG_APCC_DBOX_1

Location: 173:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9359

ASA_SCORE: 81.6333

COIL: 0.6864

CONS_SCORE: 0.4201

DSS_SCORE: 0.2743

HELIX: 0.032

FCONS_SCORE: 0.7372

RIG_SCORE: 0.8588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P172H	TCGA-DJ-A2QB	THCA	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	0.3056
p.P172H	DO39421	THCA	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.3056
p.E166K	TCGA-EO-A22U	UCEC	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	0.1389
p.E166K	DO43755	UCEC	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.1389
p.V173M	TCGA-KK-A6E2	PRAD	TCGA	VRKVLKPIQ	DEG_APCC_DBOX_1	0.6097
p.V173M	DO51356	PRAD	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.6097
p.C163F	DO229027	LICA	ICGC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.0556
p.D168N	EVSA-T	breast	COSMIC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.1944
p.I191M	NCI-H446	lung	COSMIC	VRKVLKPIQ	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2P8	RNA 3'-terminal phosphate cyclase-like protein	DEG_APCC_DBOX_1	173:181	VRKVLKPIQ	APC,CDC20,FZR1	0.9359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons