DegronMD - Q9Y2T2(AP3M1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A383D	TCGA-A5-A0G2	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.A383D	DO41235	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.G396W	TCGA-AX-A2HA	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6714
p.G396W	DO42504	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6714
p.R391H	TCGA-B5-A1MR	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.3056
p.R391H	TCGA-BR-8371	STAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.3056
p.R391H	TCGA-N9-A4Q7	UCS	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.3056
p.R391H	DO47950	STAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.3056
p.R391H	DO41758	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.3056
p.S385L	TCGA-B6-A0IO	BRCA	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1389
p.S385L	DO3067	BRCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1389
p.Y395H	TCGA-CA-6717	COAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6118
p.Y395H	DO8264	COAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6118
p.Y399C	TCGA-EL-A3CW	THCA	TCGA	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation blocking phosphorylation signal	0.7222
p.Y399C	DO48121	THCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation blocking phosphorylation signal	0.7222
p.K398R	DO52645	BOCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation blocking ubiquitination signal	0.75
p.P401Q	DO228948	LICA	ICGC	LDMYGE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.2222

Kaplan plot for AP3M1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AP3M1

UniProt ID: Q9Y2T2

Entrez ID: 26985

Protein name: AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AP3M1 in