DegronMD

Uniprot ID: Q9Y2T2

Source protein: AP-3 complex subunit mu-1

Source gene: AP3M1

Class: LIG_APCC_ABBA_1

Location: 392:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5068

ASA_SCORE: 54.4167

COIL: 0.3648

CONS_SCORE: 0.5874

DSS_SCORE: 0.1661

HELIX: 0.0082

FCONS_SCORE: 0.887

RIG_SCORE: 0.8254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A383D	TCGA-A5-A0G2	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.0833
p.A383D	DO41235	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.0833
p.G396W	TCGA-AX-A2HA	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.6714
p.G396W	DO42504	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.6714
p.R391H	TCGA-B5-A1MR	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391H	TCGA-BR-8371	STAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391H	TCGA-N9-A4Q7	UCS	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391H	DO47950	STAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391H	DO41758	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.S385L	TCGA-B6-A0IO	BRCA	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.1389
p.S385L	DO3067	BRCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.1389
p.Y395H	TCGA-CA-6717	COAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.6118
p.Y395H	DO8264	COAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.6118
p.Y399C	TCGA-EL-A3CW	THCA	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.7222
p.Y399C	DO48121	THCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.7222
p.K398R	DO52645	BOCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.75
p.P401Q	DO228948	LICA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons