DegronMD

Uniprot ID: P53677

Source protein: AP-3 complex subunit mu-2

Source gene: AP3M2

Class: LIG_APCC_ABBA_1

Location: 392:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6284

ASA_SCORE: 54.4167

COIL: 0.3575

CONS_SCORE: 0.563

DSS_SCORE: 0.1571

HELIX: 0.0112

FCONS_SCORE: 0.8622

RIG_SCORE: 0.8314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L392V	TCGA-36-2534	OV	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.5654
p.L392V	DO29046	OV	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.5654
p.K388E	TCGA-A5-A0VP	UCEC	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.6667
p.K388E	DO42600	UCEC	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.6667
p.L382R	TCGA-AA-3510	COAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.0556
p.L382R	DO7783	COAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.0556
p.I384V	TCGA-BR-6452	STAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.1111
p.I384V	DO38404	STAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.1111
p.R391C	TCGA-CA-6717	COAD	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391C	TCGA-D9-A6EC	SKCM	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391C	DO8264	COAD	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.R391C	DO50291	SKCM	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.Y395C	TCGA-D8-A73X	BRCA	TCGA	LDMYGE	LIG_APCC_ABBA_1	0.7087
p.Y395C	DO219633	BRCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.7087
p.M394V	DO233791	GACA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.6097
p.R391L	DO228948	LICA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.3056
p.S385F	DO232761	PBCA	ICGC	LDMYGE	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons