DegronMD - Q9Y303(AMDHD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L140P	TCGA-22-5477	LUSC	TCGA	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.L140P	DO26894	LUSC	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.R149W	TCGA-CG-4460	STAD	TCGA	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.R149W	DO38427	STAD	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.H133N	TCGA-D3-A2J8	SKCM	TCGA	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.H133N	DO37778	SKCM	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E143D	TCGA-HU-A4GQ	STAD	TCGA	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5647
p.E143D	DO47767	STAD	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5647
p.R152W	TCGA-XM-A8RF	THYM	TCGA	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.G136W	DO229027	LICA	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.A135S	DO229031	LICA	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.A135S	SIDM00104	Mesothelioma	GDSC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.A135S	ACH-002123	Lung Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.A135S	H2369	pleura	COSMIC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.P132L	DO220891	MELA	ICGC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.L138F	SIDM00545	Melanoma	GDSC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.587
p.L138F	ACH-000987	Skin Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.587
p.I147V	SIDM00277	Acute Myeloid Leukemia	GDSC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.R149Q	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.S129T	SIDM01182	Bladder Carcinoma	GDSC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.S129T	ACH-000522	Bladder Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.S129T	UM-UC-3	urinary tract	COSMIC	LGLHLE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833

Kaplan plot for AMDHD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMDHD2

UniProt ID: Q9Y303

Entrez ID: 51005

Protein name: N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMDHD2 in