DegronMD

Uniprot ID: Q9Y303

Source protein: N-acetylglucosamine-6-phosphate deacetylase

Source gene: AMDHD2

Class: LIG_APCC_ABBA_1

Location: 138:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7129

ASA_SCORE: 10.0167

COIL: 0.1698

CONS_SCORE: 0.7719

DSS_SCORE: 0.4274

HELIX: 0.008

FCONS_SCORE: 1.4591

RIG_SCORE: 0.7374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L140P	TCGA-22-5477	LUSC	TCGA	LGLHLE	LIG_APCC_ABBA_1	0.6471
p.L140P	DO26894	LUSC	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.6471
p.R149W	TCGA-CG-4460	STAD	TCGA	LGLHLE	LIG_APCC_ABBA_1	0.1667
p.R149W	DO38427	STAD	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.1667
p.H133N	TCGA-D3-A2J8	SKCM	TCGA	LGLHLE	LIG_APCC_ABBA_1	0.1944
p.H133N	DO37778	SKCM	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.1944
p.E143D	TCGA-HU-A4GQ	STAD	TCGA	LGLHLE	LIG_APCC_ABBA_1	0.5647
p.E143D	DO47767	STAD	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.5647
p.R152W	TCGA-XM-A8RF	THYM	TCGA	LGLHLE	LIG_APCC_ABBA_1	0.0833
p.G136W	DO229027	LICA	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.2778
p.A135S	DO229031	LICA	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.25
p.A135S	SIDM00104	Mesothelioma	GDSC	LGLHLE	LIG_APCC_ABBA_1	0.25
p.A135S	ACH-002123	Lung Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	0.25
p.A135S	H2369	pleura	COSMIC	LGLHLE	LIG_APCC_ABBA_1	0.25
p.P132L	DO220891	MELA	ICGC	LGLHLE	LIG_APCC_ABBA_1	0.1667
p.L138F	SIDM00545	Melanoma	GDSC	LGLHLE	LIG_APCC_ABBA_1	0.587
p.L138F	ACH-000987	Skin Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	0.587
p.I147V	SIDM00277	Acute Myeloid Leukemia	GDSC	LGLHLE	LIG_APCC_ABBA_1	0.2222
p.R149Q	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LGLHLE	LIG_APCC_ABBA_1	0.1667
p.S129T	SIDM01182	Bladder Carcinoma	GDSC	LGLHLE	LIG_APCC_ABBA_1	0.0833
p.S129T	ACH-000522	Bladder Cancer	CCLE	LGLHLE	LIG_APCC_ABBA_1	0.0833
p.S129T	UM-UC-3	urinary_tract	COSMIC	LGLHLE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y303	N-acetylglucosamine-6-phosphate deacetylase	LIG_APCC_ABBA_1	138:143	LGLHLE	APC,CDC20,FZR1	0.7129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons