DegronMD - Q9Y383(LUC7L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L21V	TCGA-21-1070	LUSC	TCGA	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1667
p.L21V	DO27088	LUSC	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1667
p.A2T	TCGA-VD-A8KB	UVM	TCGA	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation blocking phosphorylation signal	0.6389
p.S8A	DO230334	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.S8A	DO229010	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.S8A	DO229016	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.S8A	DO229505	LAML	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.S8A	DO231064	LUSC	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7588
p.Q6H	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.Q6H	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.Q6H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.Q6H	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.Q6H	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.L5F	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.L5F	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.L5F	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.V11F	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7068
p.V11F	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7068
p.V11F	Daudi	haematopoietic and lymphoid tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7068
p.V11F	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7068
p.G9E	SIDM00556	Neuroblastoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7199
p.G9E	KP-N-YN	autonomic ganglia	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7199
p.S18Y	SIDM00035	Thyroid Gland Carcinoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation blocking phosphorylation signal	0.6944
p.R22C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1389
p.R25C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0556
p.R24C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	7:15	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for LUC7L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LUC7L2

UniProt ID: Q9Y383

Entrez ID: 51631

Protein name: Putative RNA-binding protein Luc7-like 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LUC7L2 in