DegronMD

Uniprot ID: Q9Y383

Source protein: Putative RNA-binding protein Luc7-like 2

Source gene: LUC7L2

Class: DEG_APCC_DBOX_1

Location: 7:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9781

ASA_SCORE: 60.8778

COIL: 0.0819

CONS_SCORE: 0.5322

DSS_SCORE: 0.5808

HELIX: 0.9112

FCONS_SCORE: 1.4898

RIG_SCORE: 0.7694

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L21V	TCGA-21-1070	LUSC	TCGA	MRAMLDQLM	DEG_APCC_DBOX_1	0.1667
p.L21V	DO27088	LUSC	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.1667
p.A2T	TCGA-VD-A8KB	UVM	TCGA	MRAMLDQLM	DEG_APCC_DBOX_1	0.6389
p.S8A	DO230334	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7588
p.S8A	DO229010	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7588
p.S8A	DO229016	COCA	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7588
p.S8A	DO229505	LAML	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7588
p.S8A	DO231064	LUSC	ICGC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7588
p.Q6H	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.3056
p.Q6H	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.3056
p.Q6H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.3056
p.Q6H	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.3056
p.Q6H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.3056
p.L5F	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.2778
p.L5F	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.2778
p.L5F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.2778
p.V11F	SIDM00845	Burkitt's Lymphoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7068
p.V11F	SIDM00461	Acute Myeloid Leukemia	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7068
p.V11F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7068
p.V11F	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7068
p.G9E	SIDM00556	Neuroblastoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7199
p.G9E	KP-N-YN	autonomic_ganglia	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.7199
p.S18Y	SIDM00035	Thyroid Gland Carcinoma	GDSC	MRAMLDQLM	DEG_APCC_DBOX_1	0.6944
p.R22C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.1389
p.R25C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.0556
p.R24C	CADO-ES1	bone	COSMIC	MRAMLDQLM	DEG_APCC_DBOX_1	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRAMLDQLM

Degron related mutations and impact score

Drug responses associated with LUC7L2 mutations

All proteins holding degron of MRAMLDQLM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y383	Putative RNA-binding protein Luc7-like 2	DEG_APCC_DBOX_1	7:15	MRAMLDQLM	APC,CDC20,FZR1	0.9781	More...