DegronMD - Q9Y3B9(RRP15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C74F	TCGA-CR-6480	HNSC	TCGA	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.3056
p.C74F	DO14296	HNSC	ICGC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.3056
p.D81Y	DO228933	LICA	ICGC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.2778
p.E77K	DO50936	LICA	ICGC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation altering degron motif	0.7022
p.T88I	SIDM00422	Hodgkin's Lymphoma	GDSC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.0833
p.T88I	ACH-001203	Lymphoma	CCLE	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.0833
p.T88I	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.0833
p.G69V	SIDM00632	Non-Cancerous	GDSC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G69V	ACH-002247	Non-Cancerous	CCLE	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G69V	IM-9	haematopoietic and lymphoid tissue	COSMIC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G82E	SIDM00477	Esophageal Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.25
p.G82E	ACH-000383	Esophageal Cancer	CCLE	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.25
p.G82E	OE33	oesophagus	COSMIC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.25
p.G69C	SIDM01146	Gastric Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G69C	ACH-000932	Gastric Cancer	CCLE	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G69C	NCI-SNU-1	stomach	COSMIC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667
p.G69D	SIDM01664	Prostate Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	75:79	Mutation rewiring degron network	0.1667

Kaplan plot for RRP15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRP15

UniProt ID: Q9Y3B9

Entrez ID: 51018

Protein name: RRP15-like protein (Ribosomal RNA-processing protein 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRP15 in