DegronMD

Uniprot ID: Q9Y3B9

Source protein: RRP15-like protein

Source gene: RRP15

Class: DEG_APCC_KENBOX_2

Location: 75:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9829

ASA_SCORE: 118.32

COIL: 0.8672

CONS_SCORE: 0.4702

DSS_SCORE: 0.7465

HELIX: 0.115

FCONS_SCORE: 1.1109

RIG_SCORE: 0.6627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C74F	TCGA-CR-6480	HNSC	TCGA	DKENE	DEG_APCC_KENBOX_2	0.3056
p.C74F	DO14296	HNSC	ICGC	DKENE	DEG_APCC_KENBOX_2	0.3056
p.D81Y	DO228933	LICA	ICGC	DKENE	DEG_APCC_KENBOX_2	0.2778
p.E77K	DO50936	LICA	ICGC	DKENE	DEG_APCC_KENBOX_2	0.7022
p.T88I	SIDM00422	Hodgkin's Lymphoma	GDSC	DKENE	DEG_APCC_KENBOX_2	0.0833
p.T88I	ACH-001203	Lymphoma	CCLE	DKENE	DEG_APCC_KENBOX_2	0.0833
p.T88I	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.0833
p.G69V	SIDM00632	Non-Cancerous	GDSC	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G69V	ACH-002247	Non-Cancerous	CCLE	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G69V	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G82E	SIDM00477	Esophageal Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	0.25
p.G82E	ACH-000383	Esophageal Cancer	CCLE	DKENE	DEG_APCC_KENBOX_2	0.25
p.G82E	OE33	oesophagus	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.25
p.G69C	SIDM01146	Gastric Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G69C	ACH-000932	Gastric Cancer	CCLE	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G69C	NCI-SNU-1	stomach	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.1667
p.G69D	SIDM01664	Prostate Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6N043	Zinc finger protein 280D	DEG_APCC_KENBOX_2	807:811	DKENE	APC,CDC20,FZR1	0.9442	More...
Q9NZH4	Putative pituitary tumor-transforming gene 3 protein	DEG_APCC_KENBOX_2	8:12	DKENE	APC,CDC20,FZR1	0.9859	More...
Q9Y3B9	RRP15-like protein	DEG_APCC_KENBOX_2	75:79	DKENE	APC,CDC20,FZR1	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons