DegronMD

Uniprot ID: Q6N043

Source protein: Zinc finger protein 280D

Source gene: ZNF280D

Class: DEG_APCC_KENBOX_2

Location: 807:811

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9442

ASA_SCORE: 112.4

COIL: 0.7128

CONS_SCORE: 0.1917

DSS_SCORE: 0.5335

HELIX: 0.2004

FCONS_SCORE: 1.0735

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D816Y	TCGA-09-2043	OV	TCGA	DKENE	DEG_APCC_KENBOX_2	0.1944
p.I811V	DO15655	HNSC	ICGC	DKENE	DEG_APCC_KENBOX_2	0.7076
p.D803Y	DO29750	OV	ICGC	DKENE	DEG_APCC_KENBOX_2	0.2222
p.D821Y	DO43306	UCEC	ICGC	DKENE	DEG_APCC_KENBOX_2	0.0556
p.D815G	DO43755	UCEC	ICGC	DKENE	DEG_APCC_KENBOX_2	0.2222
p.E809V	SIDM00564	Ovarian Carcinoma	GDSC	DKENE	DEG_APCC_KENBOX_2	0.7693
p.E809V	ACH-000527	Ovarian Cancer	CCLE	DKENE	DEG_APCC_KENBOX_2	0.7693
p.E809V	OVISE	ovary	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.7693
p.S806L	LoVo	large_intestine	COSMIC	DKENE	DEG_APCC_KENBOX_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6N043	Zinc finger protein 280D	DEG_APCC_KENBOX_2	807:811	DKENE	APC,CDC20,FZR1	0.9442	More...
Q9NZH4	Putative pituitary tumor-transforming gene 3 protein	DEG_APCC_KENBOX_2	8:12	DKENE	APC,CDC20,FZR1	0.9859	More...
Q9Y3B9	RRP15-like protein	DEG_APCC_KENBOX_2	75:79	DKENE	APC,CDC20,FZR1	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons