DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DKENE
Uniprot ID:
Q9NZH4
Source protein:
Putative pituitary tumor-transforming gene 3 protein
Source gene:
PTTG3P
Class:
DEG_APCC_KENBOX_2
Location:
8:12
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9859
ASA_SCORE:
88.7
COIL:
0.6734
CONS_SCORE:
0.8124
DSS_SCORE:
0.2988
HELIX:
0.1456
FCONS_SCORE:
1.282
RIG_SCORE:
0.8029
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PTTG3P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKENE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6N043
Zinc finger protein 280D
DEG_APCC_KENBOX_2
807:811
DKENE
APC,CDC20,FZR1
0.9442
More...
Q9NZH4
Putative pituitary tumor-transforming gene 3 protein
DEG_APCC_KENBOX_2
8:12
DKENE
APC,CDC20,FZR1
0.9859
More...
Q9Y3B9
RRP15-like protein
DEG_APCC_KENBOX_2
75:79
DKENE
APC,CDC20,FZR1
0.9829
More...