FBXO7
UniProt ID: Q9Y3I1
Entrez ID: 25793
Protein name: F-box only protein 7
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mito...
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. {ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124, ECO:0000269|PubMed:23933751}.
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GO - Biological processes (BP):
autophagy of mitochondrion [GO:0000422]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of hydrogen peroxide-induced neuron death [GO:1903208]; negative regu...
autophagy of mitochondrion [GO:0000422]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of hydrogen peroxide-induced neuron death [GO:1903208]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; positive regulation of autophagy of mitochondrion [GO:1903599]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]
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GO - Molecular function (MF):
protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]...
protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]
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GO - Cellular component (CC):
classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-contain...
classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]
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FBXO7
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Kaplan plot for FBXO7 in
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*NOTE: the Kaplan plots were collected from OncoLnc