DegronMD

Uniprot ID: Q9Y3I1

Source protein: F-box only protein 7

Source gene: FBXO7

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9284

ASA_SCORE: 35.1667

COIL: 0.9086

CONS_SCORE: 0.4756

DSS_SCORE: 0.555

HELIX: 0.036

FCONS_SCORE: 0.8966

RIG_SCORE: 0.7074

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P441L	TCGA-85-8664	LUSC	TCGA	QRPTLPYVG	DEG_APCC_DBOX_1	0.0833
p.D459Y	TCGA-AX-A2HC	UCEC	TCGA	QRPTLPYVG	DEG_APCC_DBOX_1	0.3056
p.R451I	TCGA-EY-A215	UCEC	TCGA	QRPTLPYVG	DEG_APCC_DBOX_1	0.8102
p.I461T	TCGA-IB-7651	PAAD	TCGA	QRPTLPYVG	DEG_APCC_DBOX_1	0.25
p.P460Q	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRPTLPYVG	DEG_APCC_DBOX_1	0.2778
p.P460Q	ACH-002272	Lymphoma	CCLE	QRPTLPYVG	DEG_APCC_DBOX_1	0.2778
p.P460Q	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRPTLPYVG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3I1	F-box only protein 7	DEG_APCC_DBOX_1	450:458	QRPTLPYVG	APC,CDC20,FZR1	0.9284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons