DegronMD - Q9Y3T9(NOC2L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D699N	TCGA-CF-A1HR	BLCA	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1111
p.D699N	DO469	BLCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1111
p.D699N	SIDM00414	Bladder Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1111
p.D699N	ACH-000545	Bladder Cancer	CCLE	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1111
p.D699N	VM-CUB-1	urinary tract	COSMIC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1111
p.D676Y	TCGA-CV-5432	HNSC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D676Y	DO14343	HNSC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D676G	TCGA-DI-A1BU	UCEC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D676G	DO42023	UCEC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D676N	TCGA-DK-A2I6	BLCA	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D676N	DO798	BLCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1389
p.D677A	TCGA-FI-A2D5	UCEC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1667
p.D677A	DO41331	UCEC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1667
p.S682L	DO229010	COCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.3056
p.S682L	SIDM00142	Endometrial Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.3056
p.S682L	SIDM00242	Osteosarcoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.3056
p.D677E	DO229018	LICA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.1667
p.L690Q	DO231758	LINC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation altering degron motif	0.7765
p.L690P	DO38404	STAD	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation altering degron motif	0.7582
p.R693Q	SIDM00984	Other Blood Cancers	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.R693Q	SIDM01179	Other Sarcomas	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.R693Q	SIDM00722	Mesothelioma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.R693Q	SIDM00879	Breast Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.R693Q	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.R693Q	SIDM00539	Esophageal Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.2778
p.E674A	SIDM00027	Kidney Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.0833
p.E674A	ACH-001192	Bone Cancer	CCLE	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.0833
p.E674A	SK-NEP-1	kidney	COSMIC	ERGILRPLS	DEG_APCC_DBOX_1	683:691	Mutation rewiring degron network	0.0833

Kaplan plot for NOC2L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOC2L

UniProt ID: Q9Y3T9

Entrez ID: 26155

Protein name: Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOC2L in