DegronMD

Uniprot ID: Q9Y3T9

Source protein: Nucleolar complex protein 2 homolog

Source gene: NOC2L

Class: DEG_APCC_DBOX_1

Location: 683:691

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8086

ASA_SCORE: 93.9667

COIL: 0.8176

CONS_SCORE: 0.2424

DSS_SCORE: 0.6322

HELIX: 0.1154

FCONS_SCORE: 0.9809

RIG_SCORE: 0.6678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D699N	TCGA-CF-A1HR	BLCA	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	0.1111
p.D699N	DO469	BLCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1111
p.D699N	SIDM00414	Bladder Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.1111
p.D699N	ACH-000545	Bladder Cancer	CCLE	ERGILRPLS	DEG_APCC_DBOX_1	0.1111
p.D699N	VM-CUB-1	urinary_tract	COSMIC	ERGILRPLS	DEG_APCC_DBOX_1	0.1111
p.D676Y	TCGA-CV-5432	HNSC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D676Y	DO14343	HNSC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D676G	TCGA-DI-A1BU	UCEC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D676G	DO42023	UCEC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D676N	TCGA-DK-A2I6	BLCA	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D676N	DO798	BLCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1389
p.D677A	TCGA-FI-A2D5	UCEC	TCGA	ERGILRPLS	DEG_APCC_DBOX_1	0.1667
p.D677A	DO41331	UCEC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1667
p.S682L	DO229010	COCA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.3056
p.S682L	SIDM00142	Endometrial Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.3056
p.S682L	SIDM00242	Osteosarcoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.3056
p.D677E	DO229018	LICA	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.1667
p.L690Q	DO231758	LINC	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.7765
p.L690P	DO38404	STAD	ICGC	ERGILRPLS	DEG_APCC_DBOX_1	0.7582
p.R693Q	SIDM00984	Other Blood Cancers	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.R693Q	SIDM01179	Other Sarcomas	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.R693Q	SIDM00722	Mesothelioma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.R693Q	SIDM00879	Breast Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.R693Q	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.R693Q	SIDM00539	Esophageal Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.2778
p.E674A	SIDM00027	Kidney Carcinoma	GDSC	ERGILRPLS	DEG_APCC_DBOX_1	0.0833
p.E674A	ACH-001192	Bone Cancer	CCLE	ERGILRPLS	DEG_APCC_DBOX_1	0.0833
p.E674A	SK-NEP-1	kidney	COSMIC	ERGILRPLS	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERGILRPLS

Degron related mutations and impact score

Drug responses associated with NOC2L mutations

All proteins holding degron of ERGILRPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3T9	Nucleolar complex protein 2 homolog	DEG_APCC_DBOX_1	683:691	ERGILRPLS	APC,CDC20,FZR1	0.8086	More...