DegronMD - Q9Y3Y2(CHTOP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R103L	TCGA-86-8073	LUAD	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1944
p.R103Q	TCGA-99-8028	LUAD	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1944
p.R103Q	DO23561	LUAD	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1944
p.R118C	TCGA-A5-A1OF	UCEC	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2222
p.R118C	DO42568	UCEC	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2222
p.I107T	TCGA-AA-3715	COAD	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.3056
p.R121C	TCGA-EY-A1GI	UCEC	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R121C	DO41211	UCEC	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R121H	TCGA-L9-A7SV	LUAD	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R121H	DO49875	LUAD	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R121H	ACH-000697	Lymphoma	CCLE	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R121H	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.G101R	TCGA-Z2-AA3V	SKCM	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.G101E	TCGA-Z2-AA3V	SKCM	TCGA	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.G101E	DO51303	SKCM	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R109Q	DO223079	ESCA	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation altering degron motif	0.7329
p.G120V	DO229037	LICA	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1667
p.G120E	DO231070	LUSC	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1667
p.P101H	DO37431	SKCM	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.G110S	DO51277	SKCM	ICGC	IQRGLPR	SCF_FBXL2	108:114	Mutation altering degron motif	0.6993
p.G103E	SIDM00557	Neuroblastoma	GDSC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1944
p.G103E	KP-N-RT-BM-1	autonomic ganglia	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1944
p.R122H	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1111
p.R122H	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1111
p.R104Q	SIDM00633	Breast Carcinoma	GDSC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2222
p.G117E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.25
p.G117E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.25
p.I101V	SIDM01157	Other Solid Cancers	GDSC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.I101V	SW954	vulva	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1389
p.R124G	ACH-000332	Pancreatic Cancer	CCLE	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.0556
p.R124G	YAPC	pancreas	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.0556
p.G102E	ACH-000345	Neuroblastoma	CCLE	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1667
p.G102E	KP-N-RT-BM-1	autonomic ganglia	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1667
p.G116E	ACH-002256	Leukemia	CCLE	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2778
p.G116E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2778
p.R99G	YAPC	pancreas	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.0833
p.R118Q	A2780	ovary	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.2222
p.R115Q	NCI-H2030	lung	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.3056
p.I100V	SW954	vulva	COSMIC	IQRGLPR	SCF_FBXL2	108:114	Mutation rewiring degron network	0.1111

Kaplan plot for CHTOP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHTOP

UniProt ID: Q9Y3Y2

Entrez ID: 26097

Protein name: Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHTOP in