DegronMD

Uniprot ID: Q9Y3Y2

Source protein: Chromatin target of PRMT1 protein

Source gene: CHTOP

Class: SCF_FBXL2

Location: 108:114

E3 ligase: FBXL2

DEGRON score: 0.9514

ASA_SCORE: 85.6143

COIL: 0.7499

CONS_SCORE: 0.6073

DSS_SCORE: 0.4208

HELIX: 0.0429

FCONS_SCORE: 0.8817

RIG_SCORE: 0.755

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R103L	TCGA-86-8073	LUAD	TCGA	IQRGLPR	SCF_FBXL2	0.1944
p.R103Q	TCGA-99-8028	LUAD	TCGA	IQRGLPR	SCF_FBXL2	0.1944
p.R103Q	DO23561	LUAD	ICGC	IQRGLPR	SCF_FBXL2	0.1944
p.R118C	TCGA-A5-A1OF	UCEC	TCGA	IQRGLPR	SCF_FBXL2	0.2222
p.R118C	DO42568	UCEC	ICGC	IQRGLPR	SCF_FBXL2	0.2222
p.I107T	TCGA-AA-3715	COAD	TCGA	IQRGLPR	SCF_FBXL2	0.3056
p.R121C	TCGA-EY-A1GI	UCEC	TCGA	IQRGLPR	SCF_FBXL2	0.1389
p.R121C	DO41211	UCEC	ICGC	IQRGLPR	SCF_FBXL2	0.1389
p.R121H	TCGA-L9-A7SV	LUAD	TCGA	IQRGLPR	SCF_FBXL2	0.1389
p.R121H	DO49875	LUAD	ICGC	IQRGLPR	SCF_FBXL2	0.1389
p.R121H	ACH-000697	Lymphoma	CCLE	IQRGLPR	SCF_FBXL2	0.1389
p.R121H	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	IQRGLPR	SCF_FBXL2	0.1389
p.G101R	TCGA-Z2-AA3V	SKCM	TCGA	IQRGLPR	SCF_FBXL2	0.1389
p.G101E	TCGA-Z2-AA3V	SKCM	TCGA	IQRGLPR	SCF_FBXL2	0.1389
p.G101E	DO51303	SKCM	ICGC	IQRGLPR	SCF_FBXL2	0.1389
p.R109Q	DO223079	ESCA	ICGC	IQRGLPR	SCF_FBXL2	0.7329
p.G120V	DO229037	LICA	ICGC	IQRGLPR	SCF_FBXL2	0.1667
p.G120E	DO231070	LUSC	ICGC	IQRGLPR	SCF_FBXL2	0.1667
p.P101H	DO37431	SKCM	ICGC	IQRGLPR	SCF_FBXL2	0.1389
p.G110S	DO51277	SKCM	ICGC	IQRGLPR	SCF_FBXL2	0.6993
p.G103E	SIDM00557	Neuroblastoma	GDSC	IQRGLPR	SCF_FBXL2	0.1944
p.G103E	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	IQRGLPR	SCF_FBXL2	0.1944
p.R122H	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQRGLPR	SCF_FBXL2	0.1111
p.R122H	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	IQRGLPR	SCF_FBXL2	0.1111
p.R104Q	SIDM00633	Breast Carcinoma	GDSC	IQRGLPR	SCF_FBXL2	0.2222
p.G117E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IQRGLPR	SCF_FBXL2	0.25
p.G117E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IQRGLPR	SCF_FBXL2	0.25
p.I101V	SIDM01157	Other Solid Cancers	GDSC	IQRGLPR	SCF_FBXL2	0.1389
p.I101V	SW954	vulva	COSMIC	IQRGLPR	SCF_FBXL2	0.1389
p.R124G	ACH-000332	Pancreatic Cancer	CCLE	IQRGLPR	SCF_FBXL2	0.0556
p.R124G	YAPC	pancreas	COSMIC	IQRGLPR	SCF_FBXL2	0.0556
p.G102E	ACH-000345	Neuroblastoma	CCLE	IQRGLPR	SCF_FBXL2	0.1667
p.G102E	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	IQRGLPR	SCF_FBXL2	0.1667
p.G116E	ACH-002256	Leukemia	CCLE	IQRGLPR	SCF_FBXL2	0.2778
p.G116E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IQRGLPR	SCF_FBXL2	0.2778
p.R99G	YAPC	pancreas	COSMIC	IQRGLPR	SCF_FBXL2	0.0833
p.R118Q	A2780	ovary	COSMIC	IQRGLPR	SCF_FBXL2	0.2222
p.R115Q	NCI-H2030	lung	COSMIC	IQRGLPR	SCF_FBXL2	0.3056
p.I100V	SW954	vulva	COSMIC	IQRGLPR	SCF_FBXL2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQRGLPR

Degron related mutations and impact score

Drug responses associated with CHTOP mutations

All proteins holding degron of IQRGLPR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Y2	Chromatin target of PRMT1 protein	SCF_FBXL2	108:114	IQRGLPR	FBXL2	0.9514	More...