DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
YWHAH-AS1
UniProt ID:
Q9Y442
Entrez ID:
25775
Protein name:
Putative uncharacterized protein YWHAH-AS1 (YWHAH antisense RNA 1)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]...
integral component of membrane [GO:0016021]
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YWHAH-AS1
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.I147S
TCGA-AA-A010
COAD
TCGA
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation altering degron motif
0.7341
p.P148S
TCGA-DA-A95Z
SKCM
TCGA
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation altering degron motif
0.5641
p.P148S
DO219481
SKCM
ICGC
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation altering degron motif
0.5641
p.S158A
DO230659
LAML
ICGC
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation rewiring degron network
0.2222
p.S158A
DO231140
LAML
ICGC
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation rewiring degron network
0.2222
p.A159E
DO229045
LICA
ICGC
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation rewiring degron network
0.1944
p.Q143R
DO223282
UCEC
ICGC
IPATPYIS
DEG_SCF_FBW7_1
147:154
Mutation rewiring degron network
0.2222
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for YWHAH-AS1 in
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Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc