DegronMD

Uniprot ID: Q9Y442

Source protein: Putative uncharacterized protein YWHAH-AS1

Source gene: YWHAH-AS1

Class: DEG_SCF_FBW7_1

Location: 147:154

E3 ligase: FBXW7

DEGRON score: 0.7374

ASA_SCORE: 45.7375

COIL: 0.7163

CONS_SCORE: 0.8561

DSS_SCORE: 0.3503

HELIX: 0.1974

FCONS_SCORE: 0.9478

RIG_SCORE: 0.8103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I147S	TCGA-AA-A010	COAD	TCGA	IPATPYIS	DEG_SCF_FBW7_1	0.7341
p.P148S	TCGA-DA-A95Z	SKCM	TCGA	IPATPYIS	DEG_SCF_FBW7_1	0.5641
p.P148S	DO219481	SKCM	ICGC	IPATPYIS	DEG_SCF_FBW7_1	0.5641
p.S158A	DO230659	LAML	ICGC	IPATPYIS	DEG_SCF_FBW7_1	0.2222
p.S158A	DO231140	LAML	ICGC	IPATPYIS	DEG_SCF_FBW7_1	0.2222
p.A159E	DO229045	LICA	ICGC	IPATPYIS	DEG_SCF_FBW7_1	0.1944
p.Q143R	DO223282	UCEC	ICGC	IPATPYIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y442	Putative uncharacterized protein YWHAH-AS1	DEG_SCF_FBW7_1	147:154	IPATPYIS	FBXW7	0.7374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons