MTF2
UniProt ID: Q9Y483
Entrez ID: 22823
Protein name: Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic...
FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}.
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GO - Biological processes (BP):
cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; negative regulation of histone H3-K27 methylation [GO:0061086]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone H3-K27 methylation [GO:0061087]; p...
cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; negative regulation of histone H3-K27 methylation [GO:0061086]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]...
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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MTF2
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Kaplan plot for MTF2 in
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*NOTE: the Kaplan plots were collected from OncoLnc