DegronMD

Uniprot ID: Q9Y483

Source protein: Metal-response element-binding transcription factor 2

Source gene: MTF2

Class: LIG_APCC_ABBA_1

Location: 77:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 45.2833

COIL: 0.2775

CONS_SCORE: 0.5146

DSS_SCORE: 0.0286

HELIX: 0.0158

FCONS_SCORE: 1.3012

RIG_SCORE: 0.9734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F80C	DO50448	ESAD	ICGC	FIIFED	LIG_APCC_ABBA_1	0.7108
p.L73V	DO39690	THCA	ICGC	FIIFED	LIG_APCC_ABBA_1	0.3333
p.A91T	HCT-15	large_intestine	COSMIC	FIIFED	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y483	Metal-response element-binding transcription factor 2	LIG_APCC_ABBA_1	77:82	FIIFED	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons