DegronMD - Q9Y485(DMXL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D339Y	TCGA-77-7141	LUSC	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.D339Y	DO26450	LUSC	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.R321W	TCGA-B5-A1MR	UCEC	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.7523
p.R321W	DO8264	COAD	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.7523
p.R321W	DO41758	UCEC	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.7523
p.E311K	TCGA-EE-A2MT	SKCM	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.E311K	TCGA-PE-A5DE	BRCA	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.E311K	DO219643	BRCA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.E311K	DO38051	SKCM	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0556
p.R318C	TCGA-FW-A3R5	SKCM	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.25
p.R318C	DO37406	SKCM	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.25
p.G332V	DO229038	LICA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.25
p.V328L	DO229009	LICA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.5654
p.T331R	ACH-000650	Skin Cancer	CCLE	RRRSLALVA	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons