DegronMD

Uniprot ID: Q9Y485

Source protein: DmX-like protein 1

Source gene: DMXL1

Class: DEG_APCC_DBOX_1

Location: 321:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.535

ASA_SCORE: 98.3778

COIL: 0.6752

CONS_SCORE: 0.2643

DSS_SCORE: 0.4052

HELIX: 0.2497

FCONS_SCORE: 0.8321

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D339Y	TCGA-77-7141	LUSC	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.D339Y	DO26450	LUSC	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.R321W	TCGA-B5-A1MR	UCEC	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	0.7523
p.R321W	DO8264	COAD	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.7523
p.R321W	DO41758	UCEC	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.7523
p.E311K	TCGA-EE-A2MT	SKCM	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.E311K	TCGA-PE-A5DE	BRCA	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.E311K	DO219643	BRCA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.E311K	DO38051	SKCM	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.0556
p.R318C	TCGA-FW-A3R5	SKCM	TCGA	RRRSLALVA	DEG_APCC_DBOX_1	0.25
p.R318C	DO37406	SKCM	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.25
p.G332V	DO229038	LICA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.25
p.V328L	DO229009	LICA	ICGC	RRRSLALVA	DEG_APCC_DBOX_1	0.5654
p.T331R	ACH-000650	Skin Cancer	CCLE	RRRSLALVA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y485	DmX-like protein 1	DEG_APCC_DBOX_1	321:329	RRRSLALVA	APC,CDC20,FZR1	0.535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons