DegronMD - Q9Y490(TLN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2526W	TCGA-AP-A1DK	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation altering degron motif	0.7523
p.P2534S	TCGA-B5-A1MX	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.1111
p.R2526Q	TCGA-BC-A10Z	LIHC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation altering degron motif	0.6218
p.R2510W	TCGA-EO-A3AV	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.1111
p.R2519Q	TCGA-HU-8249	STAD	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation altering degron motif	0.7329
p.R2510L	SIDM00183	Small Cell Lung Carcinoma	GDSC	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.1111
p.R2510L	ACH-002154	Lung Cancer	CCLE	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.1111
p.R2510L	LB647-SCLC	lung	COSMIC	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.1111
p.E2514V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.2222
p.E2514V	ACH-000937	Leukemia	CCLE	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.2222
p.E2514V	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARKKLAQIR	DEG_APCC_DBOX_1	2518:2526	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons