DegronMD

Uniprot ID: Q9Y490

Source protein: Talin-1

Source gene: TLN1

Class: DEG_APCC_DBOX_1

Location: 2518:2526

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6657

ASA_SCORE: 79.5778

COIL: 0.0158

CONS_SCORE: 0.525

DSS_SCORE: 0.3434

HELIX: 0.9848

FCONS_SCORE: 1.0902

RIG_SCORE: 0.7911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2526W	TCGA-AP-A1DK	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	0.7523
p.P2534S	TCGA-B5-A1MX	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	0.1111
p.R2526Q	TCGA-BC-A10Z	LIHC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	0.6218
p.R2510W	TCGA-EO-A3AV	UCEC	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	0.1111
p.R2519Q	TCGA-HU-8249	STAD	TCGA	ARKKLAQIR	DEG_APCC_DBOX_1	0.7329
p.R2510L	SIDM00183	Small Cell Lung Carcinoma	GDSC	ARKKLAQIR	DEG_APCC_DBOX_1	0.1111
p.R2510L	ACH-002154	Lung Cancer	CCLE	ARKKLAQIR	DEG_APCC_DBOX_1	0.1111
p.R2510L	LB647-SCLC	lung	COSMIC	ARKKLAQIR	DEG_APCC_DBOX_1	0.1111
p.E2514V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ARKKLAQIR	DEG_APCC_DBOX_1	0.2222
p.E2514V	ACH-000937	Leukemia	CCLE	ARKKLAQIR	DEG_APCC_DBOX_1	0.2222
p.E2514V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ARKKLAQIR	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y490	Talin-1	DEG_APCC_DBOX_1	2518:2526	ARKKLAQIR	APC,CDC20,FZR1	0.6657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons