DegronMD - Q9Y4D1(DAAM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1041H	TCGA-2Y-A9H4	LIHC	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0833
p.D1034Y	TCGA-91-7771	LUAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.2778
p.R1018H	TCGA-BR-4361	STAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0833
p.R1018C	TCGA-DU-6392	LGG	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0833
p.E1017G	TCGA-EO-A22R	UCEC	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0556
p.L1036I	TCGA-ER-A19F	SKCM	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.2222
p.R1041C	TCGA-F4-6570	COAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0833
p.R1041L	TCGA-IB-7651	PAAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.0833
p.G1033V	DO458	BLCA	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.3056
p.R1031C	DO10443	COAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.8301
p.R1031C	DO51518	PACA	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.8301
p.V1035L	DO7784	COAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.25
p.R1031H	DO219527	LIHC	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.8244
p.R1031H	DO232759	PBCA	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.8244
p.D1024Y	DO25807	LUAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation substituting flanking lysine	0.3611
p.R1031L	DO46657	PAAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.8428
p.G1021R	DO52151	PAEN	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.1667
p.L1026I	DO37679	SKCM	ICGC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.3056
p.L1036R	SIDM01090	Colorectal Carcinoma	GDSC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.2222
p.L1036R	ACH-000943	Colon/Colorectal Cancer	CCLE	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.2222
p.L1036R	RKO	large intestine	COSMIC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.2222
p.S1038L	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.1667
p.S1038L	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.1667
p.A1039D	ACH-001839	Bile Duct Cancer	CCLE	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.1389
p.S1028L	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation altering degron motif	0.7667
p.L1026R	RKO	large intestine	COSMIC	SEESGE	DEG_Kelch_Keap1_1	1027:1032	Mutation rewiring degron network	0.3056

Kaplan plot for DAAM1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAAM1

UniProt ID: Q9Y4D1

Entrez ID: 23002

Protein name: Disheveled-associated activator of morphogenesis 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DAAM1 in