DegronMD

Uniprot ID: Q9Y4D1

Source protein: Disheveled-associated activator of morphogenesis 1

Source gene: DAAM1

Class: DEG_Kelch_Keap1_1

Location: 1027:1032

E3 ligase: KEAP1

DEGRON score: 0.5155

ASA_SCORE: 93.3167

COIL: 0.74

CONS_SCORE: 0.3275

DSS_SCORE: 0.4904

HELIX: 0.2417

FCONS_SCORE: 0.815

RIG_SCORE: 0.6122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1041H	TCGA-2Y-A9H4	LIHC	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0833
p.D1034Y	TCGA-91-7771	LUAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.2778
p.R1018H	TCGA-BR-4361	STAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0833
p.R1018C	TCGA-DU-6392	LGG	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0833
p.E1017G	TCGA-EO-A22R	UCEC	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0556
p.L1036I	TCGA-ER-A19F	SKCM	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.2222
p.R1041C	TCGA-F4-6570	COAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0833
p.R1041L	TCGA-IB-7651	PAAD	TCGA	SEESGE	DEG_Kelch_Keap1_1	0.0833
p.G1033V	DO458	BLCA	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.3056
p.R1031C	DO10443	COAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.8301
p.R1031C	DO51518	PACA	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.8301
p.V1035L	DO7784	COAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.25
p.R1031H	DO219527	LIHC	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.8244
p.R1031H	DO232759	PBCA	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.8244
p.D1024Y	DO25807	LUAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.3611
p.R1031L	DO46657	PAAD	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.8428
p.G1021R	DO52151	PAEN	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.1667
p.L1026I	DO37679	SKCM	ICGC	SEESGE	DEG_Kelch_Keap1_1	0.3056
p.L1036R	SIDM01090	Colorectal Carcinoma	GDSC	SEESGE	DEG_Kelch_Keap1_1	0.2222
p.L1036R	ACH-000943	Colon/Colorectal Cancer	CCLE	SEESGE	DEG_Kelch_Keap1_1	0.2222
p.L1036R	RKO	large_intestine	COSMIC	SEESGE	DEG_Kelch_Keap1_1	0.2222
p.S1038L	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEESGE	DEG_Kelch_Keap1_1	0.1667
p.S1038L	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	SEESGE	DEG_Kelch_Keap1_1	0.1667
p.A1039D	ACH-001839	Bile Duct Cancer	CCLE	SEESGE	DEG_Kelch_Keap1_1	0.1389
p.S1028L	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	SEESGE	DEG_Kelch_Keap1_1	0.7667
p.L1026R	RKO	large_intestine	COSMIC	SEESGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D1	Disheveled-associated activator of morphogenesis 1	DEG_Kelch_Keap1_1	1027:1032	SEESGE	KEAP1	0.5155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEESGE

Degron related mutations and impact score

Drug responses associated with DAAM1 mutations

All proteins holding degron of SEESGE