TELO2
UniProt ID: Q9Y4R8
Entrez ID: 9894
Protein name: Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing ...
FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
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GO - Biological processes (BP):
positive regulation of DNA damage checkpoint [GO:2000003]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein stabilization [GO:0050821]; regulation of TOR sig...
positive regulation of DNA damage checkpoint [GO:2000003]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]; telomere maintenance via telomerase [GO:0007004]
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GO - Molecular function (MF):
Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; protein kinase binding [GO:0019901]; telomeric DNA binding [GO:0042162]...
Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; protein kinase binding [GO:0019901]; telomeric DNA binding [GO:0042162]
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GO - Cellular component (CC):
ASTRA complex [GO:0070209]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078...
ASTRA complex [GO:0070209]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT complex [GO:0110078]
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TELO2
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Kaplan plot for TELO2 in
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*NOTE: the Kaplan plots were collected from OncoLnc