DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KVLLHLE
Uniprot ID:
Q9Y4R8
Source protein:
Telomere length regulation protein TEL2 homolog
Source gene:
TELO2
Class:
LIG_APCC_ABBAyCdc20_2
Location:
558:564
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6042
ASA_SCORE:
43.7714
COIL:
0.369
CONS_SCORE:
0.5897
DSS_SCORE:
0.0396
HELIX:
0.6097
FCONS_SCORE:
1.2191
RIG_SCORE:
0.9203
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L561M
TCGA-EE-A29M
SKCM
TCGA
KVLLHLE
LIG_APCC_ABBAyCdc20_2
0.5999
p.L561M
DO37404
SKCM
ICGC
KVLLHLE
LIG_APCC_ABBAyCdc20_2
0.5999
Drug responses associated with TELO2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KVLLHLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4R8
Telomere length regulation protein TEL2 homolog
LIG_APCC_ABBAyCdc20_2
558:564
KVLLHLE
APC,CDC20,FZR1
0.6042
More...