DegronMD - Q9Y4U1(MMACHC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A237V	TCGA-FI-A2D5	UCEC	TCGA	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5825
p.A237V	DO41331	UCEC	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.5825
p.F223V	DO233642	GACA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.L231F	DO228978	LICA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.587
p.R230L	DO229031	LICA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8428
p.P243S	SIDM00422	Hodgkin's Lymphoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.P243S	ACH-001203	Lymphoma	CCLE	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.P243S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1667
p.A228V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.A228V	SIDM00324	Neuroblastoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.A228V	SIDM01444	Glioblastoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.A228V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.A228V	TGW	autonomic ganglia	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.P226A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25
p.P226A	H513	pleura	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.25

Kaplan plot for MMACHC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMACHC

UniProt ID: Q9Y4U1

Entrez ID: 25974

Protein name: Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMACHC in