DegronMD

Uniprot ID: Q9Y4U1

Source protein: Cyanocobalamin reductase / alkylcobalamin dealkylase

Source gene: MMACHC

Class: DEG_APCC_DBOX_1

Location: 229:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9267

ASA_SCORE: 50.8778

COIL: 0.1693

CONS_SCORE: 0.6343

DSS_SCORE: 0.6115

HELIX: 0.8242

FCONS_SCORE: 1.069

RIG_SCORE: 0.7214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A237V	TCGA-FI-A2D5	UCEC	TCGA	QRLALLGLA	DEG_APCC_DBOX_1	0.5825
p.A237V	DO41331	UCEC	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	0.5825
p.F223V	DO233642	GACA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	0.1667
p.L231F	DO228978	LICA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	0.587
p.R230L	DO229031	LICA	ICGC	QRLALLGLA	DEG_APCC_DBOX_1	0.8428
p.P243S	SIDM00422	Hodgkin's Lymphoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	0.1667
p.P243S	ACH-001203	Lymphoma	CCLE	QRLALLGLA	DEG_APCC_DBOX_1	0.1667
p.P243S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	0.1667
p.A228V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	0.3056
p.A228V	SIDM00324	Neuroblastoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	0.3056
p.A228V	SIDM01444	Glioblastoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	0.3056
p.A228V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	0.3056
p.A228V	TGW	autonomic_ganglia	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	0.3056
p.P226A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	QRLALLGLA	DEG_APCC_DBOX_1	0.25
p.P226A	H513	pleura	COSMIC	QRLALLGLA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4U1	Cyanocobalamin reductase / alkylcobalamin dealkylase	DEG_APCC_DBOX_1	229:237	QRLALLGLA	APC,CDC20,FZR1	0.9267	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons