DegronMD - Q9Y4Z2(NEUROG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P5S	TCGA-A5-A2K3	UCEC	TCGA	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.5641
p.P5S	DO43899	UCEC	ICGC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.5641
p.T2M	TCGA-AX-A3G9	UCEC	TCGA	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T2M	DO41241	UCEC	ICGC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.E16K	TCGA-CN-6998	HNSC	TCGA	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.E16K	DO15519	HNSC	ICGC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.E16K	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.E16K	ACH-000628	Lung Cancer	CCLE	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.E16K	NCI-H596	lung	COSMIC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.R15P	TCGA-E2-A14T	BRCA	TCGA	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.R15P	DO5109	BRCA	ICGC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.T10S	TCGA-XE-A8H5	TGCT	TCGA	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.2222
p.R15C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.R15C	ACH-000995	Leukemia	CCLE	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.R15C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.E16Q	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.E16Q	SIDM01749	Osteosarcoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556

Kaplan plot for NEUROG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEUROG3

UniProt ID: Q9Y4Z2

Entrez ID: 50674

Protein name: Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEUROG3 in