DegronMD

Uniprot ID: Q9Y4Z2

Source protein: Neurogenin-3

Source gene: NEUROG3

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.9821

ASA_SCORE: 101.0667

COIL: 0.9723

CONS_SCORE: 0.5077

DSS_SCORE: 0.9557

HELIX: 0.0138

FCONS_SCORE: 1.5066

RIG_SCORE: 0.5986

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P5S	TCGA-A5-A2K3	UCEC	TCGA	MTPQPS	DEG_SCF_FBW7_1	0.5641
p.P5S	DO43899	UCEC	ICGC	MTPQPS	DEG_SCF_FBW7_1	0.5641
p.T2M	TCGA-AX-A3G9	UCEC	TCGA	MTPQPS	DEG_SCF_FBW7_1	0.7423
p.T2M	DO41241	UCEC	ICGC	MTPQPS	DEG_SCF_FBW7_1	0.7423
p.E16K	TCGA-CN-6998	HNSC	TCGA	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.E16K	DO15519	HNSC	ICGC	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.E16K	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.E16K	ACH-000628	Lung Cancer	CCLE	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.E16K	NCI-H596	lung	COSMIC	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.R15P	TCGA-E2-A14T	BRCA	TCGA	MTPQPS	DEG_SCF_FBW7_1	0.0833
p.R15P	DO5109	BRCA	ICGC	MTPQPS	DEG_SCF_FBW7_1	0.0833
p.T10S	TCGA-XE-A8H5	TGCT	TCGA	MTPQPS	DEG_SCF_FBW7_1	0.2222
p.R15C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MTPQPS	DEG_SCF_FBW7_1	0.0833
p.R15C	ACH-000995	Leukemia	CCLE	MTPQPS	DEG_SCF_FBW7_1	0.0833
p.R15C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MTPQPS	DEG_SCF_FBW7_1	0.0833
p.E16Q	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	0.0556
p.E16Q	SIDM01749	Osteosarcoma	GDSC	MTPQPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4Z2	Neurogenin-3	DEG_SCF_FBW7_1	1:6	MTPQPS	FBXW7	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons