DegronMD - Q9Y534(CSDC2)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L137M	TCGA-EO-A3KX	UCEC	TCGA	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation rewiring degron network	0.2778
p.L137M	DO219774	UCEC	ICGC	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation rewiring degron network	0.2778
p.E144D	TCGA-XK-AAJP	PRAD	TCGA	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation altering degron motif	0.5647
p.E144D	DO51410	PRAD	ICGC	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation altering degron motif	0.5647
p.Q149H	DO228971	LICA	ICGC	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation rewiring degron network	0.2222
p.V130L	DO229037	LICA	ICGC	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation rewiring degron network	0.0833
p.V151M	ACH-000947	Ovarian Cancer	CCLE	PHTPHET	DEG_SCF_FBW7_1	139:145	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons