DegronMD

Uniprot ID: Q9Y534

Source protein: Cold shock domain-containing protein C2

Source gene: CSDC2

Class: DEG_SCF_FBW7_1

Location: 139:145

E3 ligase: FBXW7

DEGRON score: 0.637

ASA_SCORE: 89.2571

COIL: 0.8347

CONS_SCORE: 0.4227

DSS_SCORE: 0.4318

HELIX: 0.051

FCONS_SCORE: 0.8251

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L137M	TCGA-EO-A3KX	UCEC	TCGA	PHTPHET	DEG_SCF_FBW7_1	0.2778
p.L137M	DO219774	UCEC	ICGC	PHTPHET	DEG_SCF_FBW7_1	0.2778
p.E144D	TCGA-XK-AAJP	PRAD	TCGA	PHTPHET	DEG_SCF_FBW7_1	0.5647
p.E144D	DO51410	PRAD	ICGC	PHTPHET	DEG_SCF_FBW7_1	0.5647
p.Q149H	DO228971	LICA	ICGC	PHTPHET	DEG_SCF_FBW7_1	0.2222
p.V130L	DO229037	LICA	ICGC	PHTPHET	DEG_SCF_FBW7_1	0.0833
p.V151M	ACH-000947	Ovarian Cancer	CCLE	PHTPHET	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y534	Cold shock domain-containing protein C2	DEG_SCF_FBW7_1	139:145	PHTPHET	FBXW7	0.637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons