DegronMD - Q9Y5A6(ZSCAN21)

ZSCAN21

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R125W	TCGA-61-2092	OV	TCGA	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.R125W	DO32449	OV	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.Q141H	TCGA-C5-A1BJ	CESC	TCGA	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.3056
p.Q141H	DO49009	CESC	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.3056
p.P138L	TCGA-D3-A8GC	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation altering degron motif	0.6471
p.P138L	DO50281	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation altering degron motif	0.6471
p.L127M	TCGA-FS-A1ZB	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.1389
p.L127M	DO37886	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.1389
p.S149F	TCGA-FW-A3R5	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.S149F	DO37406	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.R125Q	DO23290	LINC	ICGC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.S149P	ACH-000608	Ovarian Cancer	CCLE	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation rewiring degron network	0.0833
p.G147V	KP-N-YN	autonomic ganglia	COSMIC	VSTPPNE	DEG_SCF_FBW7_2	134:140	Mutation substituting flanking lysine	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc