DegronMD

Uniprot ID: Q9Y5A6

Source protein: Zinc finger and SCAN domain-containing protein 21

Source gene: ZSCAN21

Class: DEG_SCF_FBW7_2

Location: 134:140

E3 ligase: FBXW7

DEGRON score: 0.5347

ASA_SCORE: 92.2857

COIL: 0.9136

CONS_SCORE: 0.4994

DSS_SCORE: 0.7289

HELIX: 0.031

FCONS_SCORE: 0.8836

RIG_SCORE: 0.5977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R125W	TCGA-61-2092	OV	TCGA	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.R125W	DO32449	OV	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.Q141H	TCGA-C5-A1BJ	CESC	TCGA	VSTPPNE	DEG_SCF_FBW7_2	0.3056
p.Q141H	DO49009	CESC	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.3056
p.P138L	TCGA-D3-A8GC	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	0.6471
p.P138L	DO50281	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.6471
p.L127M	TCGA-FS-A1ZB	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	0.1389
p.L127M	DO37886	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.1389
p.S149F	TCGA-FW-A3R5	SKCM	TCGA	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.S149F	DO37406	SKCM	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.R125Q	DO23290	LINC	ICGC	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.S149P	ACH-000608	Ovarian Cancer	CCLE	VSTPPNE	DEG_SCF_FBW7_2	0.0833
p.G147V	KP-N-YN	autonomic_ganglia	COSMIC	VSTPPNE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5A6	Zinc finger and SCAN domain-containing protein 21	DEG_SCF_FBW7_2	134:140	VSTPPNE	FBXW7	0.5347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons