DegronMD - Q9Y5B6(PAXBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F376V	TCGA-85-6561	LUSC	TCGA	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation altering degron motif	0.5957
p.F376V	DO26518	LUSC	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation altering degron motif	0.5957
p.K377N	TCGA-BR-8680	STAD	TCGA	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation altering degron motif	0.5806
p.K377N	DO47769	STAD	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation altering degron motif	0.5806
p.T373K	DO229022	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.F376L	DO229026	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation altering degron motif	0.587
p.A365D	DO229031	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.0556
p.T387N	DO229038	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.1944
p.P385L	SIDM00545	Melanoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.25
p.P385L	ACH-000987	Skin Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.25
p.P385L	Mewo	skin	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.25
p.T384A	SIDM00845	Burkitt's Lymphoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	SIDM00461	Acute Myeloid Leukemia	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	SIDM01519	Head and Neck Carcinoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	ACH-000037	Sarcoma	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	ACH-000786	Lymphoma	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	ACH-000992	Head and Neck Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	S-117	soft tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.T384A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2778
p.D389Y	ACH-001516	Cervical Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.1389
p.V386I	ACH-001652	Endometrial/Uterine Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	375:382	Mutation rewiring degron network	0.2222

Kaplan plot for PAXBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAXBP1

UniProt ID: Q9Y5B6

Entrez ID: 94104

Protein name: PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAXBP1 in