DegronMD

Uniprot ID: Q9Y5B6

Source protein: PAX3- and PAX7-binding protein 1

Source gene: PAXBP1

Class: DEG_SCF_FBW7_2

Location: 375:382

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 94.1625

COIL: 0.9328

CONS_SCORE: 0.2457

DSS_SCORE: 0.5401

HELIX: 0.0344

FCONS_SCORE: 0.8928

RIG_SCORE: 0.708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F376V	TCGA-85-6561	LUSC	TCGA	PFKTPSNE	DEG_SCF_FBW7_2	0.5957
p.F376V	DO26518	LUSC	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.5957
p.K377N	TCGA-BR-8680	STAD	TCGA	PFKTPSNE	DEG_SCF_FBW7_2	0.5806
p.K377N	DO47769	STAD	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.5806
p.T373K	DO229022	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.F376L	DO229026	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.587
p.A365D	DO229031	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.0556
p.T387N	DO229038	LICA	ICGC	PFKTPSNE	DEG_SCF_FBW7_2	0.1944
p.P385L	SIDM00545	Melanoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.25
p.P385L	ACH-000987	Skin Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.25
p.P385L	Mewo	skin	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	0.25
p.T384A	SIDM00845	Burkitt's Lymphoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	SIDM00461	Acute Myeloid Leukemia	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	SIDM01519	Head and Neck Carcinoma	GDSC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	ACH-000037	Sarcoma	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	ACH-000786	Lymphoma	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	ACH-000992	Head and Neck Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	S-117	soft_tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.T384A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PFKTPSNE	DEG_SCF_FBW7_2	0.2778
p.D389Y	ACH-001516	Cervical Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.1389
p.V386I	ACH-001652	Endometrial/Uterine Cancer	CCLE	PFKTPSNE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5B6	PAX3- and PAX7-binding protein 1	DEG_SCF_FBW7_2	375:382	PFKTPSNE	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFKTPSNE

Degron related mutations and impact score

Drug responses associated with PAXBP1 mutations

All proteins holding degron of PFKTPSNE