DegronMD - Q9Y5E6(PCDHB3)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S184C	TCGA-23-2645	OV	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.0556
p.S184C	DO30890	OV	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.0556
p.V180I	TCGA-AA-3877	COAD	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.1667
p.V180I	DO7855	COAD	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.1667
p.E158G	TCGA-AJ-A3EL	UCEC	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.1389
p.E158G	DO41542	UCEC	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.1389
p.T173A	TCGA-AP-A054	UCEC	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.6028
p.T173A	DO42256	UCEC	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.6028
p.S166I	TCGA-AX-A06F	UCEC	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.623
p.S166I	DO41752	UCEC	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.623
p.P174L	TCGA-CM-6168	COAD	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.7582
p.P174L	DO9602	COAD	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.7582
p.P174L	SIDM00545	Melanoma	GDSC	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.7582
p.P174L	ACH-000987	Skin Cancer	CCLE	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.7582
p.P174L	Mewo	skin	COSMIC	NSLQNYTITP	CBL_PTK	165:174	Mutation altering degron motif	0.7582
p.D161G	TCGA-EO-A3B0	UCEC	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.2222
p.D161G	DO219773	UCEC	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.2222
p.R164T	TCGA-IR-A3LK	CESC	TCGA	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.3056
p.R164T	DO44299	CESC	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.3056
p.R183H	DO233272	GACA	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.0833
p.R183H	SIDM02032	Pancreatic Carcinoma	GDSC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.0833
p.S176F	DO227588	ORCA	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.2778
p.D159H	DO233452	PRAD	ICGC	NSLQNYTITP	CBL_PTK	165:174	Mutation rewiring degron network	0.1667

Kaplan plot for PCDHB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHB3

UniProt ID: Q9Y5E6

Entrez ID: 56132

Protein name: Protocadherin beta-3 (PCDH-beta-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHB3 in