DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NSLQNYTITP
Uniprot ID:
Q9Y5E6
Source protein:
Protocadherin beta-3
Source gene:
PCDHB3
Class:
CBL_PTK
Location:
165:174
E3 ligase:
CBL
DEGRON score:
0.786
ASA_SCORE:
62.01
COIL:
0.5323
CONS_SCORE:
0.5724
DSS_SCORE:
0.3893
HELIX:
0.0254
FCONS_SCORE:
0.8984
RIG_SCORE:
0.7405
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S184C
TCGA-23-2645
OV
TCGA
NSLQNYTITP
CBL_PTK
0.0556
p.S184C
DO30890
OV
ICGC
NSLQNYTITP
CBL_PTK
0.0556
p.V180I
TCGA-AA-3877
COAD
TCGA
NSLQNYTITP
CBL_PTK
0.1667
p.V180I
DO7855
COAD
ICGC
NSLQNYTITP
CBL_PTK
0.1667
p.E158G
TCGA-AJ-A3EL
UCEC
TCGA
NSLQNYTITP
CBL_PTK
0.1389
p.E158G
DO41542
UCEC
ICGC
NSLQNYTITP
CBL_PTK
0.1389
p.T173A
TCGA-AP-A054
UCEC
TCGA
NSLQNYTITP
CBL_PTK
0.6028
p.T173A
DO42256
UCEC
ICGC
NSLQNYTITP
CBL_PTK
0.6028
p.S166I
TCGA-AX-A06F
UCEC
TCGA
NSLQNYTITP
CBL_PTK
0.623
p.S166I
DO41752
UCEC
ICGC
NSLQNYTITP
CBL_PTK
0.623
p.P174L
TCGA-CM-6168
COAD
TCGA
NSLQNYTITP
CBL_PTK
0.7582
p.P174L
DO9602
COAD
ICGC
NSLQNYTITP
CBL_PTK
0.7582
p.P174L
SIDM00545
Melanoma
GDSC
NSLQNYTITP
CBL_PTK
0.7582
p.P174L
ACH-000987
Skin Cancer
CCLE
NSLQNYTITP
CBL_PTK
0.7582
p.P174L
Mewo
skin
COSMIC
NSLQNYTITP
CBL_PTK
0.7582
p.D161G
TCGA-EO-A3B0
UCEC
TCGA
NSLQNYTITP
CBL_PTK
0.2222
p.D161G
DO219773
UCEC
ICGC
NSLQNYTITP
CBL_PTK
0.2222
p.R164T
TCGA-IR-A3LK
CESC
TCGA
NSLQNYTITP
CBL_PTK
0.3056
p.R164T
DO44299
CESC
ICGC
NSLQNYTITP
CBL_PTK
0.3056
p.R183H
DO233272
GACA
ICGC
NSLQNYTITP
CBL_PTK
0.0833
p.R183H
SIDM02032
Pancreatic Carcinoma
GDSC
NSLQNYTITP
CBL_PTK
0.0833
p.S176F
DO227588
ORCA
ICGC
NSLQNYTITP
CBL_PTK
0.2778
p.D159H
DO233452
PRAD
ICGC
NSLQNYTITP
CBL_PTK
0.1667
Drug responses associated with PCDHB3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSLQNYTITP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5E6
Protocadherin beta-3
CBL_PTK
165:174
NSLQNYTITP
CBL
0.786
More...