DegronMD - Q9Y5F3(PCDHB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E388A	TCGA-19-1388	GBM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.659
p.E388A	DO13797	GBM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.659
p.K381N	TCGA-AD-6901	COAD	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation substituting flanking lysine	0.3056
p.K381N	DO9218	COAD	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation substituting flanking lysine	0.3056
p.T397K	TCGA-B5-A11N	UCEC	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.T397K	DO41458	UCEC	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.F398S	TCGA-B5-A1MX	UCEC	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.2222
p.F398S	DO41999	UCEC	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.2222
p.G379R	TCGA-FW-A3R5	SKCM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1389
p.G379R	DO37406	SKCM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1389
p.P391S	TCGA-FW-A3R5	SKCM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.5641
p.P391S	DO37406	SKCM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.5641
p.G380E	DO222644	MELA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1667
p.F398L	DO222662	MELA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.2222
p.G399E	DO229502	SKCA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.G399E	SIDM00150	Colorectal Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.G399E	ACH-000969	Colon/Colorectal Cancer	CCLE	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.G399E	KM12	large intestine	COSMIC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.L390F	SIDM00629	Breast Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00454	Rhabdomyosarcoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00633	Breast Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00907	Burkitt's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM00720	Mesothelioma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM01664	Prostate Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.L390F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.6981
p.R377Q	SIDM01198	Burkitt's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.0833
p.R377Q	ACH-000567	Lymphoma	CCLE	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.0833
p.R377Q	ST486	haematopoietic and lymphoid tissue	COSMIC	LREDLPFVI	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.0833

Kaplan plot for PCDHB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHB1

UniProt ID: Q9Y5F3

Entrez ID: 29930

Protein name: Protocadherin beta-1 (PCDH-beta-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHB1 in