DegronMD

Uniprot ID: Q9Y5F3

Source protein: Protocadherin beta-1

Source gene: PCDHB1

Class: DEG_APCC_DBOX_1

Location: 386:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5711

ASA_SCORE: 65.1

COIL: 0.6181

CONS_SCORE: 0.4297

DSS_SCORE: 0.0782

HELIX: 0.0092

FCONS_SCORE: 0.8854

RIG_SCORE: 0.9221

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E388A	TCGA-19-1388	GBM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.659
p.E388A	DO13797	GBM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.659
p.K381N	TCGA-AD-6901	COAD	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.3056
p.K381N	DO9218	COAD	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.3056
p.T397K	TCGA-B5-A11N	UCEC	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.25
p.T397K	DO41458	UCEC	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.25
p.F398S	TCGA-B5-A1MX	UCEC	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.2222
p.F398S	DO41999	UCEC	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.2222
p.G379R	TCGA-FW-A3R5	SKCM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.1389
p.G379R	DO37406	SKCM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.1389
p.P391S	TCGA-FW-A3R5	SKCM	TCGA	LREDLPFVI	DEG_APCC_DBOX_1	0.5641
p.P391S	DO37406	SKCM	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.5641
p.G380E	DO222644	MELA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.1667
p.F398L	DO222662	MELA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.2222
p.G399E	DO229502	SKCA	ICGC	LREDLPFVI	DEG_APCC_DBOX_1	0.1944
p.G399E	SIDM00150	Colorectal Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.1944
p.G399E	ACH-000969	Colon/Colorectal Cancer	CCLE	LREDLPFVI	DEG_APCC_DBOX_1	0.1944
p.G399E	KM12	large_intestine	COSMIC	LREDLPFVI	DEG_APCC_DBOX_1	0.1944
p.L390F	SIDM00629	Breast Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00454	Rhabdomyosarcoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00633	Breast Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00907	Burkitt's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM00720	Mesothelioma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM01664	Prostate Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.L390F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.6981
p.R377Q	SIDM01198	Burkitt's Lymphoma	GDSC	LREDLPFVI	DEG_APCC_DBOX_1	0.0833
p.R377Q	ACH-000567	Lymphoma	CCLE	LREDLPFVI	DEG_APCC_DBOX_1	0.0833
p.R377Q	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LREDLPFVI	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LREDLPFVI

Degron related mutations and impact score

Drug responses associated with PCDHB1 mutations

All proteins holding degron of LREDLPFVI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5F3	Protocadherin beta-1	DEG_APCC_DBOX_1	386:394	LREDLPFVI	APC,CDC20,FZR1	0.5711	More...