DegronMD - Q9Y5G8(PCDHGA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S306L	TCGA-17-Z010	LUAD	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1667
p.V328F	TCGA-50-5931	LUAD	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1111
p.V328F	DO228976	LICA	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1111
p.V328F	DO24980	LUAD	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1111
p.M317I	TCGA-66-2727	LUSC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6507
p.M317I	TCGA-D1-A103	UCEC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6507
p.M317I	DO26478	LUSC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6507
p.M317I	DO42312	UCEC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.6507
p.R313I	TCGA-AX-A2HC	UCEC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.8102
p.R313I	DO41572	UCEC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.8102
p.A326T	TCGA-EA-A410	CESC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1667
p.A326T	DO49929	CESC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1667
p.G325S	DO229081	PRAD	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.1944
p.Q322R	SIDM00960	Colorectal Carcinoma	GDSC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.2778
p.Q322R	ACH-000798	Colon/Colorectal Cancer	CCLE	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.2778
p.Q322R	CL-40	large intestine	COSMIC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.2778
p.Y315C	SIDM00505	Pancreatic Carcinoma	GDSC	SRFYLMEVV	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.5976

Kaplan plot for PCDHGA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGA5

UniProt ID: Q9Y5G8

Entrez ID: 56110

Protein name: Protocadherin gamma-A5 (PCDH-gamma-A5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGA5 in