DegronMD

Uniprot ID: Q9Y5G8

Source protein: Protocadherin gamma-A5

Source gene: PCDHGA5

Class: DEG_APCC_DBOX_1

Location: 312:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8206

ASA_SCORE: 55.3889

COIL: 0.2346

CONS_SCORE: 0.5066

DSS_SCORE: 0.1302

HELIX: 0.0092

FCONS_SCORE: 0.7807

RIG_SCORE: 0.9136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S306L	TCGA-17-Z010	LUAD	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.1667
p.V328F	TCGA-50-5931	LUAD	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.1111
p.V328F	DO228976	LICA	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.1111
p.V328F	DO24980	LUAD	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.1111
p.M317I	TCGA-66-2727	LUSC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.6507
p.M317I	TCGA-D1-A103	UCEC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.6507
p.M317I	DO26478	LUSC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.6507
p.M317I	DO42312	UCEC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.6507
p.R313I	TCGA-AX-A2HC	UCEC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.8102
p.R313I	DO41572	UCEC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.8102
p.A326T	TCGA-EA-A410	CESC	TCGA	SRFYLMEVV	DEG_APCC_DBOX_1	0.1667
p.A326T	DO49929	CESC	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.1667
p.G325S	DO229081	PRAD	ICGC	SRFYLMEVV	DEG_APCC_DBOX_1	0.1944
p.Q322R	SIDM00960	Colorectal Carcinoma	GDSC	SRFYLMEVV	DEG_APCC_DBOX_1	0.2778
p.Q322R	ACH-000798	Colon/Colorectal Cancer	CCLE	SRFYLMEVV	DEG_APCC_DBOX_1	0.2778
p.Q322R	CL-40	large_intestine	COSMIC	SRFYLMEVV	DEG_APCC_DBOX_1	0.2778
p.Y315C	SIDM00505	Pancreatic Carcinoma	GDSC	SRFYLMEVV	DEG_APCC_DBOX_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5G8	Protocadherin gamma-A5	DEG_APCC_DBOX_1	312:320	SRFYLMEVV	APC,CDC20,FZR1	0.8206	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons