DegronMD - Q9Y5H7(PCDHA5)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q520K	TCGA-49-AAR4	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1111
p.Q520K	DO218920	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1111
p.P502R	TCGA-49-AARQ	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1944
p.P502R	DO51189	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1944
p.S513R	TCGA-55-8511	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation blocking phosphorylation signal	0.75
p.S513R	DO24940	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation blocking phosphorylation signal	0.75
p.V498L	TCGA-86-8358	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0833
p.V498L	DO25471	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0833
p.A511S	TCGA-91-7771	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6477
p.A511S	DO25807	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6477
p.S508L	TCGA-A2-A0D4	BRCA	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.S508L	TCGA-EE-A182	SKCM	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.S508L	TCGA-W3-AA1R	SKCM	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.S508L	DO5347	BRCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.S508L	DO37814	SKCM	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.S508L	DO51275	SKCM	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6556
p.R497Q	TCGA-A5-A0G2	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	TCGA-A6-6648	COAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	DO10196	COAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	DO41235	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	ACH-002313	Lymphoma	CCLE	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.R497Q	TK	haematopoietic and lymphoid tissue	COSMIC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.0556
p.G514S	TCGA-A6-3809	COAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.2778
p.G514S	DO8722	COAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.2778
p.Y517H	TCGA-AP-A054	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1944
p.Y517H	DO42256	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1944
p.R501H	TCGA-AP-A1DK	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1667
p.R501H	DO42033	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1667
p.E500G	DO48385	BLCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1389
p.S504L	DO48369	BLCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.25
p.A518V	DO45079	LINC	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1667
p.R501P	DO231018	LUSC	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1667
p.E500K	DO229268	THCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1389
p.E500K	SIDM00545	Melanoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1389
p.E500K	ACH-000987	Skin Cancer	CCLE	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1389
p.E500K	Mewo	skin	COSMIC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1389
p.Q520H	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1111
p.Q520H	A427	lung	COSMIC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation rewiring degron network	0.1111
p.A511T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6028
p.A511T	ACH-002059	Leukemia	CCLE	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6028
p.A511T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation altering degron motif	0.6028
p.K515N	SIDM00333	Endometrial Carcinoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation substituting flanking lysine	0.3611
p.K515N	ACH-000988	Endometrial/Uterine Cancer	CCLE	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation substituting flanking lysine	0.3611
p.K515N	MFE-319	endometrium	COSMIC	VSVHAE	LIG_APCC_ABBA_1	507:512	Mutation substituting flanking lysine	0.3611

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHA5

UniProt ID: Q9Y5H7

Entrez ID: 56143

Protein name: Protocadherin alpha-5 (PCDH-alpha-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHA5 in